Skip to main content
. 2019 Jun 19;317(3):F695–F704. doi: 10.1152/ajprenal.00085.2019

Fig. 4.

Fig. 4.

Renal expression of injury-related genes [platelet-derived growth factor-A (PDGFA), matrix metalloproteinase (MMP)-2, p21, and p16] in aged male mice with targeted disruption of the heme oxygenase (HO)-2 gene (HO-2−/− mice) and littermate control (HO-2+/+) mice on day 2 after acute renal ischemia (IR). mRNA expression of PDGFA (A), MMP-2 (B), p21 (C), and p16 (D) was determined by quantitative real-time RT-PCR. Values are means ± SE; n = 4 mice subjected to sham surgery and n = 11 HO-2+/+ and 12 HO-2−/− mice subjected to IR. *P < 0.05 vs. HO-2+/+ mice subjected to IR.