Fig. 8.

Renal microsomal heme oxygenase (HO) activity (A) and renal HO-1 mRNA expression (B) in aged male mice with targeted disruption of the HO-2 gene (HO-2^−/− mice) and littermate control (HO-2^+/+) mice 6 h after acute renal ischemia (IR). Values are means ± SE; n = 4 mice subjected to sham surgery and n = 9 mice subjected to IR in A and n = 4 mice subjected to sham surgery and n = 7 HO-2^+/+ and 8 HO-2^−/− mice subjected to IR in B. *P < 0.05 vs. HO-2^+/+ mice subjected to IR; †P < 0.05 vs. HO-2^+/+ mice subjected to sham surgery.