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. 2019 Jun 5;317(2):L283–L294. doi: 10.1152/ajplung.00337.2018

Fig. 6.

Fig. 6.

Alveolar epithelial cells (AEC) inhibit TGF-β-stimulated type 1 collagen (COL1A1) and smooth muscle actin (ACTA2) in fibroblasts in direct cocultures. Epithelial cells and fibroblasts were cultured alone or together on collagen-coated tissue culture wells. After 2 days for adherence, the cells were cultured with or without transforming growth factor-β (TGF-β) and with 1 mg/ml bovine serum albumin (BSA) or 5% FBS for 3 days until harvest. There were 7 independent experiments with 1 mg/ml BSA and 4 with 5% FBS. *Comparison of fibroblast expression with and without TGF-β under identical conditions, P < 0.05; #comparison of fibroblast expression with or without alveolar epithelial cells under identical conditions, P < 0.05; †comparison of fibroblast expression with or without alveolar epithelial cells in the presence of TGF-β, P < 0.05. The panels are as follows: A: COL1A1; B: ACTA2; C: FN1; D: HGF; E: FGF7; F: FGF10; and G: CTGF.