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Skin blood flow response to reactive hyperemia is normalized after exercise training in heart failure with reduced ejection fraction (HFrEF) patients (pretraining, closed triangles; posttraining, open triangles). Data are means ± SE. PU, perfusion units. Effect of group, P = 0.03; effect of time and interaction, P < 0.001; *P < 0.001 HFrEF pre- vs. both posttraining (n = 27) and healthy control subjects (closed circles; n = 18).
