Table 1.
Variable | HFrEF Pretraining (n = 27) | HFrEF Posttraining (n = 27) | Healthy Subjects (n = 18) |
---|---|---|---|
Age, yr | 65 ± 2 | 66 ± 2 | 57 ± 2† |
Height, cm | 171 ± 2 | 171 ± 2 | 172 ± 3 |
Body weight, kg | 78.5 ± 3 | 80.7 ± 3 | 74 ± 4 |
BMI, kg/m2 | 26 ± 1 | 27 ± 1 | 25 ± 1 |
Heart rate, beats/min | 63 ± 2 | 63 ± 2 | 64 ± 2 |
Systolic blood pressure, mmHg | 111 ± 3 | 113 ± 3 | 115 ± 4 |
Diastolic blood pressure, mmHg | 62 ± 1 | 63 ± 2 | 68 ± 2† |
Augmentation index, % | 27.4 ± 1.7 | 28.6 ± 2.0 | 16.7 ± 3.2† |
Augmentation index at HR75, % | 20.7 ± 1.8 | 23.6 ± 2.0 | 12.9 ± 2.3† |
Skin blood flow, PU | 7.4 ± 0.6 | 7.9 ± 0.5 | 8.4 ± 1.0 |
Cutaneous vascular conductance, PU/mmHg | 9.6 ± 0.8 | 9.9 ± 0.5 | 10.3 ± 1.5 |
MSNA, bursts/min | 52.6 ± 2.5 | 47.0 ± 2.6* | 44.0 ± 2.0** |
MSNA, bursts/100 heartbeats | 83.7 ± 3.5 | 76.4 ± 4.5* | 70.0 ± 3.6** |
Peak work rate, W | 96 ± 14 | 119 ± 15* | 152 ± 18** |
V̇o2peak, L/min | 1.47 ± 0.1 | 1.69 ± 0.1* | 2.3 ± 0.2† |
V̇o2peak, mL·kg−1·min−1 | 18.3 ± 1.5 | 21.4 ± 1.7* | 30.6 ± 2.2† |
V̇o2peak, %predicted | 76.8 ± 5.2 | 87.6 ± 5.3* | 110.3 ± 6.5† |
Values are means ± SE; n as shown except for muscle sympathetic nerve activity (MSNA; n = 18). BMI, body mass index; V̇o2peak, peak oxygen uptake; HFrEF heart failure with reduced ejection fraction; HR75, heart rate of 75 beats/min; PU, perfusion units.
P < 0.05 pre- vs. posttraining HFrEF subjects;
P < 0.05 healthy controls vs. pretraining only;
P < 0.05 healthy controls vs. posttraining.