Table 2.
Effect of vehicle controls for TRPV1 antagonists on the peak pressor and cardioaccelerator responses to injecting chemicals into superficial epigastric artery
| 10% Ethanol/10% Tween 80 |
0.5% DMSO |
100% Saline |
0.1% Ethanol |
|||||
|---|---|---|---|---|---|---|---|---|
| Chemicals | Before | After | Before | After | Before | After | Before | After |
| Capsaicin | ||||||||
| MAP | 36 ± 11 | 42 ± 25 | 63 ± 29 | 70 ± 26 | 35 ± 8 | 38 ± 10 | 34 ± 20 | 43 ± 25 |
| HR | 10 ± 9 | 13 ± 11 | 4 ± 2 | 4 ± 2 | 2 ± 3 | 3 ± 2 | 3 ± 1 | 2 ± 1 |
| n | 6 | 4 | 4 | 4 | ||||
| Bradykinin | ||||||||
| MAP | 23 ± 8 | 29 ± 14 | Not tested | Not tested | 21 ± 12 | 19 ± 8 | ||
| HR | 2 ± 1 | 3 ± 2 | 1 ± 1 | 2 ± 2 | ||||
| n | 5 | 3 | ||||||
| α-β-Methylene ATP | ||||||||
| MAP | 22 ± 12 | 21 ± 9 | Not tested | Not tested | Not tested | |||
| HR | 3 ± 1 | 2 ± 1 | ||||||
| n | 9 | |||||||
| Diprotonated phosphate | ||||||||
| MAP | 33 ± 24 | 37 ± 26 | Not tested | Not tested | Not tested | |||
| HR | 4 ± 4 | 4 ± 2 | ||||||
| n | 5 | |||||||
Results are presented as means ± SD increase in mean arterial blood pressure (MAP, in mmHg) or heart rate (HR, in beats/min), evoked by each chemical; n = sample size. Note that no significant difference in the pressor or cardioaccelerator response was found for any of the vehicles that were injected into the superficial epigastric artery. TRPV1, transient receptor potential vanilloid-1.