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Serum glucose (A) and insulin (B) during a glucose tolerance test (GTT) performed 29 days after rats received bilateral ventromedial nucleus of the hypothalamus (VMH) injections of blank-saporin (Blk-Sap) or leptin-conjugated saporin (Lep-Sap). There was no effect of saporin treatment on glucose clearance or insulin release. Data are means ± SE for 16 Blk-Sap and 18 Lep-Sap rats. Significant differences were tested for by a repeated-measures ANOVA.
