Fig. 4.

Weight of 1 inguinal or 1 epididymal fat pad dissected and weighed 14 days after the start of 4th ventricle infusions of PBS or leptin in rats that had received bilateral ventromedial nucleus of the hypothalamus injections of blank-saporin (Blk-Sap) or leptin-conjugated saporin (Lep-Sap) 35 days before the start of infusion. Values for either inguinal or epididymal fat that do not share a common superscript are significantly different at P < 0.05. Data are means + SE for groups of 8–11 rats. Significant differences were determined by 2-way ANOVA followed by a post hoc Tukey’s honestly significant difference test.