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. 2019 Oct 22;9:1105. doi: 10.3389/fonc.2019.01105

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Copyright © 2019 Wang, Wang, Li, Zhang, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GO and KEGG functional analyses. (A) Gene ontology (GO) analysis of potential targets of miRNAs. The biological process (BP), cellular component (CC), and molecular function (MF) of potential targets were clustered based on ClusterProfiler package in R software (version: 3.12.0). The abscissa strands for gene counts and the ordinate means the enriched pathways. (B) The enriched KEGG signaling pathways were selected to demonstrate the primary biological actions of major potential targets. The abscissa indicates gene ratio and the enriched pathways were presented in the ordinate. (C) The has_circ_0000517 regulatory Network. The pathways, hub genes, miRNAs were presented in outer circle, middle circle and inner circle, respectively.