Table 1.
Correlation between hsa_circ_0000517 expression and clinicopathological characteristics of 60 HCC patients.
| Clinicopathological characteristics | hsa_circ_0000517 expression | P-value | χ2 | |
|---|---|---|---|---|
| Low (30) | High (30) | |||
| Age (years) | 0.26 | 1.27 | ||
| ≤50 | 11 | 7 | ||
| >50 | 19 | 23 | ||
| Gender | 0.09 | 2.96 | ||
| Male | 25 | 29 | ||
| Female | 5 | 1 | ||
| Hepatitis virus infection | 1 | 0 | ||
| HBsAg(+) | 24 | 24 | ||
| HBsAg(–) | 6 | 6 | ||
| Child–Pugh | 0.31 | 1.02 | ||
| A | 30 | 29 | ||
| B | 0 | 1 | ||
| C | 0 | 0 | ||
| Cirrhosis | 0.80 | 0.07 | ||
| Yes | 14 | 15 | ||
| No | 16 | 15 | ||
| AFP (μg/L) | 0.44 | 0.60 | ||
| ≤400 | 17 | 14 | ||
| >400 | 13 | 16 | ||
| TNM stage | 0.02* | 5.71 | ||
| I+II | 16 | 7 | ||
| III+IV | 14 | 23 | ||
| Tumor size (cm) | 0.09 | 2.86 | ||
| ≤5 | 12 | 6 | ||
| >5 | 18 | 24 | ||
| Vascular invasion | 0.18 | 1.83 | ||
| Yes | 17 | 22 | ||
| No | 13 | 8 | ||
| Histological grade | 0.67 | 0.81 | ||
| G1 | 4 | 2 | ||
| G2 | 13 | 13 | ||
| G3 | 13 | 15 | ||
(a) The median expression value of hsa_circ_0000517 was used as the cutoff. Low hsa_circ_0000517 expression in each of the 30 patients was defined as a value below the 50th percentile. (b) χ2 test, *P < 0.05. (c) TNM stage: T, Tumor; N, nodes; M, Metastasis. (d) AFP, alpha-fetoprotein; HBsAg, the hepatitis B surface antigen.