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. 2019 Aug 8;317(4):G476–G483. doi: 10.1152/ajpgi.00112.2019

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Fig. 4. — Microinjection of bicuculline in the dorsal vagal complex (DVC) induced a larger increase in antrum tone and motility in female high estrogen (HE) rats. A: representative recordings from the antrum of a male (top, black), female low estrogen (LE) (middle, blue), and female-HE (bottom, red) showing the increase in antrum tone and motility upon microinjection (upward arrow) of bicuculline (0.5 pmol/60 nL). Note the increase in tone and motility in female-HE rats is larger compared with male and female-LE rats. B: summary graph representing the effects of bicuculline (0.1 pmol and 0.5 pmol) microinjection in the DVC on antrum tone in male (black), female-LE (blue), and female-HE (red) rats. Note that both 0.1 and 0.5 pmol bicuculline-induced increase in antrum tone is significantly larger in female-HE rats. *P < 0.05 vs. male. C: summary graph representing the effects of bicuculline (0.1 pmol and 0.5 pmol) microinjection in the DVC on corpus motility in male (black), female-LE (blue), and female-HE (red) rats. Note that 0.5 pmol bicuculline-induced increase in antrum motility is significantly larger in female-HE rats. *P < 0.05 vs. male.