Fig. 1.

Oral digoxin reduced hepatic damage and steatosis when given therapeutically. A–C: mice were fed with high-fat diet (HFD) for 10 wk, and then cocurrently started digoxin at multiple dosages (H, High: 2.5 mg/kg; M, middle: 0.5 mg/kg; L, low: 0.125 mg/kg), INT-767 (30 mg/kg) or vehicle twice a week by gavage feeding with continued HFD feeding for a total of 15 wk. A: digoxin reduces HFD-induced hepatic steatosis from histological analysis by hematoxylin-and-eosin (H&E)-stained sections. B: digoxin reduces HFD-induced hepatic steatosis and liver inflammation as scored quantitatively from H&E-stained sections. C: digoxin reduces HFD-induced hepatocellular damage, as measured by the serum ALT. All data in the figure show means ± SD from 8 to 10 mice in each group. *P < 0.05, **P < 0.01. Scale bar: 100 μm.