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. 2019 Oct 23;13:447. doi: 10.3389/fncel.2019.00447

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Copyright © 2019 Wang, Liu, Hou, Zhang, Kang, Wang, Zhao, Chen, Liu, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of over-expressing aGSK-3β in Shank3b^−/− ACC on social behavior. (A) Three-chamber tests of control Shank3b^−/− mice and Shank3b^−/− mice treated with aGSK-3β at 3 weeks after virus injection. Notice that aGSK-3β treatment significantly rescued the social preference of Shank3b^−/− mice. (B) Resident-juvenile-intruder home-cage test of control Shank3b^−/− mice and Shank3b^−/− mice treated with aGSK-3β. Notice that aGSK-3β treatment significantly enhanced social contact of Shank3b^−/− mice with juvenile intruder. Values represent mean ± SEM. **P < 0.01. ***P < 0.001. N = 15 mice per group (A,B). One-way ANOVA (A). Student’s t-test (B).