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. 2019 Jul 19;317(4):F805–F814. doi: 10.1152/ajprenal.00141.2019

Fig. 2.

Fig. 2.

Uptake of hydrochlorothiazide (HCTZ) by renal transporters [human organic cation transporter 2 (hOCT2), human multidrug and toxin extrusion proteins 1 and 2-K (hMATE1 and hMATE2-K), and human organic anion transporters 1 and 3 (hOAT1 and hOAT3). Uptake of 10 μM HCTZ in transporter-expressing (black) and control (white) human embryonic kidney-293 cells was measured. Uptake was measured after a 5-min incubation at 37°C. Data are presented as means ± SD. **P < 0.01 and ***P < 0.001, uptake was significantly higher in transporter-expressing cells than in control cells.