Fig. 3.

Representative immunohistological staining for kidney injury molecule-1 (KIM-1) in kidney tissue sections from diabetic mice and sodium citrate (NaC)-treated controls. There was a modest increase in KIM-1 staining intensity in proximal tubules from wild-type (WT) streptozotocin (STZ)-treated mice. Levels of KIM-1 were also higher in glomeruli of STZ-treated WT mice compared with their NaC-treated nondiabetic counterparts. In contrast, KIM-1 staining intensities were comparable in NaC-treated and STZ-treated meprin-β knockout (βKO) mice.