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Immunolocalization of TNF receptor (TNFR)1 in kidney tissue from wild-type (WT) and meprin-β knockout (βKO) mice with streptozotocin (STZ)-induced type 1 diabetes. A: immunohistochemical staining with anti-TNFR1 antibodies was used to evaluate expression of TNFR1. B: intensity of TNFR staining in glomeruli was quantified using ImageJ, and the data were analyzed by two-way ANOVA. ****P = 0.0001.
