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Summary of potential meprin involvement in kidney injury based on identified meprin substrates present in the kidney. The identified substrates suggest that meprins modulate inflammation and extracellular matrix metabolism, key underlying causes of fibrosis and kidney injury in diabetes. DKD, diabetic kidney disease; MCP-1, monocyte chemoattractant protein 1; OS-9, osteosarcoma amplified-9; TGF-β, transforming growth factor-β; HIF-1α, hypoxia-inducible factor-1α.
