Table 10.
Impact of testosterone on castrated male urinary physiology
| Castrated Male Mice | Castrated Male Mice With Testosterone | P Value | |
|---|---|---|---|
| Gross assessment | |||
| n | 14 | 8 | |
| Body mass, g | 21.51 (SD 1.53) | 23.65 (SD 1.95) | 0.0023* |
| Bladder volume, mm3/g body mass | 18.04 (SD 11.71) | 33.57 (SD 19.49) | 0.0192* |
| Prostate mass, % body mass | 0.03 (SD 0) | 0.21 (SD 0.06) | <0.0001* |
| Anterior mass, % body mass | 0.02 (SD 0) | 0.10 (SD 0.03) | <0.0001* |
| Ventral mass, % body mass | 0.01 (SD 0) | 0.05 (SD 0.03) | <0.0001* |
| Dorsal mass, % body mass | 0.01 (SD 0) | 0.04 (SD 0) | <0.0001* |
| Lateral mass, % body mass | 0.00 (SD 0) | 0.02 (SD 0) | 0.0009* |
| Seminal vesicle mass, % body mass | 0.04 (SD 0) | 0.35 (SD 0.20) | <0.0001* |
| Void spot assay | |||
| n | 11 | 4 | |
| Count | 42.00 (SD 20.23) | 50.30 (SD 29.80) | 0.5462 |
| Total area, cm2 | 20.50 (SD 7.66) | 22.60 (SD 17.24) | 0.7419 |
| Percent area in center | 2.34 (SD 2.21) | 7.35 (SD 11.86) | 0.8645 |
| Percent area in corners | 77.40 (SD 13.13) | 72.80 (SD 30.60) | 0.6846 |
| Spots of a certain size (area) | |||
| 0−0.1 cm | 38.10 (SD 19.37) | 44.00 (SD 26.40) | 0.6410 |
| 0.1−0.25 cm | 1.36 (SD 1.43) | 2.00 (SD 1.64) | 0.5509 |
| 0.25−0.5 cm | 0.64 (SD 0.50) | 1.00 (SD 2.00) | 0.5692 |
| 0.5−1 cm | 0.46 (SD 0.70) | 0 (SD 0) | 0.3956 |
| 1−2 cm | 0.18 (SD 0.40) | 0.25 (SD 0.50) | >0.9999 |
| 2−3 cm | 0 (SD 0) | 0.50 (SD 1.00) | 0.2667 |
| 3−4 cm | 0 (SD 0) | 0 (SD 0) | >0.9999 |
| 4+ cm | 1.27 (SD 0.46) | 2.50 (SD 1.74) | 0.1692 |
| Cystometry | |||
| n | 7−8 | 8 | |
| Void duration | 0.42 (SD 0.08) | 0.51 (SD 0.11) | 0.1049 |
| Intervoid interval | 2.77 (SD 0.34) | 3.00 (SD 1.27) | 0.6444 |
| Baseline pressure | 2.21 (SD 0.74) | 2.92 (SD 1.73) | 0.3111 |
| Normalized threshold pressure | 4.75 (SD 2.06) | 3.32 (SD 1.64) | 0.1437 |
| Normalized peak void pressure | 17.20 (SD 2.12) | 16.00 (SD 4.81) | 0.5400 |
| Nonvoiding contractions | 1.46 (SD 0.71) | 3.58 (SD 1.58) | 0.0039* |
| Voided volume, ×10−2 | 4.05 (SD 0.29) | 4.60 (SD 1.81) | 0.4184 |
| Compliance, ×10−2 | 0.89 (SD 0.53) | 1.34 (SD 0.88) | 0.1840 |
| Volume flow rate, ×10−3 | 1.69 (SD 0.42) | 1.53 (SD 0.51) | 0.5159 |
| Mass-based flow rate | 23.4 (SD 8.39) | 20.60 (SD 12.93) | 0.6126 |
| Efficiency, % | 96.8 (SD 8.75) | 90.74 (SD 16.43) | 0.3993 |
Values are averages (SD); n, number of animals.
*
Statistically significant difference.