Table 5.
Impact of finasteride on male urinary physiology
| Male Mice With Oil | Male Mice With Finasteride | P Value | |
|---|---|---|---|
| Gross assessment | |||
| n | 6 | 9 | |
| Body mass, g | 24.67 (SD 0.88) | 23.53 (SD 2.19) | 0.2562 |
| Bladder | |||
| Mass, % body mass | 0.13 (SD 0.02) | 0.12 (SD 0.03) | 0.3701 |
| Volume, mm3/g body mass | 33.71 (SD 22.66) | 41.35 (SD 19.83) | 0.5016 |
| Prostate mass, % body mass | 0.21 (SD 0.02) | 0.14 (SD 0.03) | 0.0009* |
| Anterior mass, % body mass | 0.11 (SD 0.02) | 0.07 (SD 0) | 0.0004* |
| Ventral mass, % body mass | 0.05 (SD 0.02) | 0.04 (SD 0) | 0.0467* |
| Dorsal mass, % body mass | 0.03 (SD 0) | 0.03 (SD 0) | 0.3465 |
| Lateral mass, % body mass | 0.02 (SD 0) | 0.01 (SD 0) | 0.0292* |
| Seminal vesicle mass, % body mass | 0.72 (SD 0.07) | 0.33 (SD 0.09) | <0.0001* |
| Void spot assay | |||
| n | 7 | 9 | |
| Count | 23.20 (SD 13.02) | 24.10 (SD 30.3) | 0.1692 |
| Total area, cm2 | 17.00 (SD 11.45) | 18.40 (SD 13.23) | 0.8209 |
| Percent area in center | 8.82 (SD 19.95) | 12.10 (SD 33) | 0.8845 |
| Percent area in corners | 48.90 (SD 28.84) | 58.50 (SD 39.9) | 0.3610 |
| Spots of a certain size (diameter) | |||
| 0−0.1 cm | 19.90 (SD 11.54) | 21.00 (SD 27.87) | 0.8658 |
| 0.1−0.25 cm | 0.89 (SD 0.93) | 1.22 (SD 1.92) | >0.9999 |
| 0.25−0.5 cm | 0.89 (SD 0.82) | 0.22 (SD 0.45) | 0.1312 |
| 0.5−1 cm | 0.11 (SD 0.29) | 0.22 (SD 0.66) | >0.9999 |
| 1−2 cm | 0.11 (SD 0.29) | 0 (SD 0) | >0.9999 |
| 2−3 cm | 0.11 (SD 0.29) | 0.11 (SD 0.33) | >0.9999 |
| 3−4 cm | 0.11 (SD 0.29) | 0 (SD 0) | >0.9999 |
| 4+ cm | 1.11 (SD 0.82) | 1.33 (SD 0.99) | 0.8013 |
| Cystometry | |||
| n | 9 | 9 | |
| Void duration | 0.63 (SD 0.21) | 0.70 (SD 0.39) | 0.8371 |
| Intervoid interval | 3.35 (SD 1.32) | 4.74 (SD 1.26) | 0.0394 |
| Baseline pressure | 3.96 (SD 0.48) | 3.13 (SD 1.53) | 0.1590 |
| Normalized threshold pressure | 3.64 (SD 2.01) | 3.65 (SD 1.68) | 0.9965 |
| Normalized peak void pressure | 13.00 (SD 2.97) | 15.90 (SD 5.22) | 0.2011 |
| Nonvoiding contractions | 1.21 (SD 0.66) | 2.33 (SD 0.59) | 0.0755† |
| Voided volume, ×10−2 | 4.24 (SD 2.07) | 6.44 (SD 1.41) | 0.0168 |
| Compliance, ×10−2 | 1.24 (SD 0.66) | 1.89 (SD 0.93) | 0.1280 |
| Volume flow rate, ×10−3 | 1.31 (SD 0.81) | 1.87 (SD 0.69) | 0.1377 |
| Mass-based flow rate | 22.80 (SD 10.89) | 17.10 (SD 5.22) | 0.1497 |
| Efficiency, % | 108.00 (SD 61.2) | 110.00 (SD 20.55) | 0.8371 |
Values are averages (SD); n, number of animals.
*
Statistically significant difference.
†
Changes that approached significance (trend).