Table 6.

Impact of finasteride on female urinary physiology

	Female Mice With Oil	Female Mice With Finasteride	P Value
Gross assessment
n	7	5
Body mass, g	18.49 (SD 1.11)	17.50 (SD 0.69)	0.0953†
Bladder
Mass, % body mass	0.12 (SD 0)	0.12 (SD 0.02)	>0.9999
Volume, mm3/g body mass	17.82 (SD 10.27)	17.27 (SD 7.24)	0.9162
Void spot assay
n	7	5
Count	23.30 (SD 15.16)	12.20 (SD 7.06)	0.1337
Total area, cm2	22.20 (SD 7.20)	11.70 (SD 3.38)	0.0083*
Percent area in center	0.65 (SD 0.66)	0.49 (SD 0.74)	0.1698
Percent area in corners	67.50 (SD 33.34)	73.70 (SD 18.85)	0.7023
Spots of a certain size (diameter)
0−0.1 cm	17.90 (SD 13.28)	8.50 (SD 5.99)	0.1464
0.1−0.25 cm	1.29 (SD 1.88)	0.50 (SD 0.76)	0.6166
0.25−0.5 cm	0.14 (SD 0.37)	0.17 (SD 0.38)	>0.9999
0.5−1 cm	0.29 (SD 0.48)	0.33 (SD 0.47)	>0.9999
1−2 cm	0.29 (SD 0.48)	0.50 (SD 0.76)	0.7797
2−3 cm	0.14 (SD 0.37)	0.83 (SD 0.69)	0.0862†
3−4 cm	0.71 (SD 1.88)	0 (SD 0)	>0.9999
4+ cm	2.57 (SD 0.78)	1.33 (SD 0.47)	0.0087*
Cystometry
n	7	5
Void duration	0.51 (SD 0.13)	0.47 (SD 0.07)	0.5419
Intervoid interval	2.90 (SD 1.48)	2.49 (SD 0.67)	0.5803
Baseline pressure	5.70 (SD 3.31)	4.88 (SD 1.86)	0.6330
Normalized threshold pressure	11.3 (SD 4.95)	8.22 (SD 1.68)	0.2212
Normalized peak void pressure	25.2 (SD 3.49)	21.70 (SD 3.08)	0.0965†
Nonvoiding contractions	3.63 (SD 2.96)	1.64 (SD 1.05)	0.3422
Voided volume, ×10−2	4.10 (SD 1.69)	3.72 (SD 0.94)	0.6595
Compliance, ×10−2	0.29 (SD 0.10)	0.37 (SD 0.13)	0.2640
Volume flow rate, ×10−3	1.39 (SD 0.53)	1.37 (SD 0.49)	0.9335
Mass-based flow rate	17.90 (SD 23.86)	7.99 (SD 2.46)	0.4346
Efficiency, %	111.00 (SD 12.04)	114.00 (SD 14.4)	0.7246

Values are averages (SD); n, number of animals.

^*Statistically significant difference.

^†Changes that approached significance (trend).