Table 1.

Hemodynamic changes during intravenous infusion of glucagon-like peptide-1

	Normal	Total Renal Denervation (Unilateral)	Afferent Renal Nerve Denervation (Bilateral)
n	5	6	5
Mean arterial pressure, mmHg
Baseline	99 ± 3	96 ± 3	98 ± 2
10 min	115 ± 4†	104 ± 2*	107 ± 3*
20 min	120 ± 4†	106 ± 2†‡	110 ± 4†
30 min	123 ± 3†	105 ± 3*§	109 ± 3†‡
40 min	108 ± 6*	99 ± 3	106 ± 2
50 min	97 ± 5	97 ± 4	95 ± 2
60 min	101 ± 3	95 ± 3	93 ± 2
Heart rate, beats/min
Baseline	324 ± 10	340 ± 12	339 ± 8
10 min	367 ± 6†	339 ± 12	330 ± 13
20 min	416 ± 11†	353 ± 12§	339 ± 17§
30 min	443 ± 10†	367 ± 11§	349 ± 16§
40 min	435 ± 10†	373 ± 13*§	354 ± 14§
50 min	393 ± 25†	371 ± 12*	357 ± 10
60 min	382 ± 20†	364 ± 10	351 ± 8

Values are means ± SE; n = 5–6 for each group of rats.

^*P < 0.05 and

^†P < 0.01 compared with baseline;

^‡P < 0.05 and

^§P < 0.01 compared with the normal group.