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. 2019 Oct 15;10:2327. doi: 10.3389/fimmu.2019.02327

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Copyright © 2019 Olbrich, Künstner, Witte, Busch and Fähnrich.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural composition of human epidermis and basement membrane zone (BMZ). (A) Shows the composition of the human skin, including melanocytes [1] (3) and immunocompetent Langerhans cells [2] (4). The approximate distribution of pemphigus antigens within the layers of the epidermis is depicted on the right-hand side. While desmogleins 1 and 4 and desmocollin 1 are expressed in the upper layers of the epidermis; desmogleins 2 and 3 as well as desmocollin 2 and 3 are expressed in the lower layers of the epidermis. (B) Depicts the BMZ with its cellular adhesion proteins, connecting epidermis and dermis, which are the main autoantigens in pemphigoid diseases.