. 2019 Oct 15;10:2435. doi: 10.3389/fimmu.2019.02435

Table 2.

Immunophenotyping of lymphocyte subsets.

Markers	Cell type	Control group	Cocaine use disorder groups		Statistics	P-value
			Low withdrawal	High withdrawal
CD3⁺CD4⁺	Th	41.62 (2.1)^#	41.97 (2.0)^#	49.56 (2.3)^*	4.070	0.025^a
CD3⁺CD4⁺CD45RA⁺	Th naïve	19.74 (2.1)^#	12.75 (1.9)^*	12.20 (2.2)^*	4.061	0.025^a
CD3⁺CD4⁺CD45RO⁺	Th memory	38.40 (2.4)	42.70 (12.6)	41.90 (19.9)	1.668	0.434^b
CD4⁺CD27⁺CD28⁺	Early-differentiated Th cell	73.34 (3.3)^#	71.31 (3.2)^#	59.57 (3.4)^*	4.807	0.014^a
CD4⁺CD27⁻CD28⁺	Intermediate-differentiated Th cell	1.59 (2.6)^#	4.14 (9.9)	6.90 (5.7)^*	6.123	0.047^b
CD4⁺CD27⁻CD28⁻	Late-differentiated Th cell	3.78 (8.9)	10.50 (8.8)	6.79 (14.5)	3.047	0.218^b
CD3⁺CD8⁺	Tc	19.70 (2.0)	17.52 (1.9)	15.09 (2.1)	1.245	0.299^a
CD3⁺CD8⁺CD45RA⁺	Tc naïve	15.50 (12.5)^#	14.60 (6.9)	10.00 (8.5)^*	9.435	0.009^b
CD3⁺CD8⁺CD45RO⁺	Tc memory	7.28 (1.1)	9.70 (1.0)	8.14 (1.1)	1.317	0.280^a
CD8⁺CD27⁺CD28⁺	Early-differentiated Tc cell	44.33 (4.2)	45.31 (4.4)	48.55 (4.6)	0.244	0.785^a
CD8⁺CD27⁻CD28⁺	Intermediate-differentiated Tc cell	12.39 (1.4)	11.18 (1.6)	11.79 (1.6)	0.159	0.853^a
CD8⁺CD27⁻CD28⁻	Late-differentiated Tc cell	38.48 (4.9)	28.52 (5.1)	25.35 (5.3)	1.852	0.172^a
CD4/CD8	Ratio	2.66 (0.4)	2.59 (0.3)	3.5 (0.4)	2.069	0.141^a
CD3⁺CD25⁺CD69⁺	Activated T cell	0.75 (1.1)	1.25 (1.3)	0.81 (1.2)	0.938	0.626^b
CD3⁻CD19⁺	B	9.77 (1.6)^#	11.86 (1.5)	15.86 (1.7)^*	3.460	0.042^a
CD3⁻CD25⁺CD69⁺	Activated B cell	0.45 (0.8)	0.16 (0.4)	0.21 (0.6)	2.878	0.237^b
CD3⁻CD56⁺	NK	5.49 (0.6)	4.01 (0.6)	4.31 (0.7)	1.467	0.243^a
CD3⁺CD56⁺	NK T	1.07 (1.7)	0.92 (0.5)	0.78 (1.1)	0.116	0.944^b

General linear model—Mean (Standard Error).

Kruskal–Wallis—Median (Interquartile Range).

*, #x00023;: Indicate differences between groups (Tukey post-hoc test or Kruskal–Wallis post-hoc test). Th, helper T cell; Tc, cytotoxic T cell; NK, Natural Killer cell. Data represents the percentage of cells. Non-addicted control group (n = 14); CUD addicted group—low withdrawal (n = 15) and high withdrawal (n = 12).

Bold values are related to significant associations, p <0.05.