Figure 1.

Cellular composition and anatomical microstructure of the liver. (A) Shape of the liver. It is a red-brown V-shaped organ divided into right and left parts by the hepatic artery, portal vein, hepatic vein, and bile ducts. (B) The liver lobule has a hexagonal shape with a diameter of about 1 mm and thickness of about 2 mm. (C) Zonation in the lobule. Reproduced with permission from [33]. (D) Zonal heterogeneity of acetaminophen-induced hepatotoxicity. The yellow arrow indicates the flow direction. Reproduced with permission from [34].