Figure 2.
Enzymatic formation of RCS from linolenic acid (18:3) in A. thaliana. The oxygenation with LOX2 produces 13-hydroperoxo-octadecatrienoic acid (13-HPOTE) as shown, while with the isozyme 9-LOX, 9-HPOTE is produced. 13-HPOTE is cleaved by the 13-hydroperoxide lyase (13-HPL), while 9-HPOTE by the isozyme 9-HPL, producing C9 aldehydes. When the reaction starts with different unsaturated fatty acids such as linoleic acid (18:2), other sets of aldehydes are formed via a similar series of enzyme reactions.