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. 2019 Sep 20;9(10):512. doi: 10.3390/biom9100512

Figure 7.

Figure 7

Effects of PNGL on the expression levels of phosphorylated NF-κB. PNGL regulated downstream Caspase 3/8/9 signaling pathway in the ischemic brain. PNGL inhibited the NF-κB activation, it regulated neuronal apoptosis and neuroinflammation reactions caused by CIRI. (A) The protein bands of the NF-κB regulated downstream Caspase 3/8/9 signaling pathways in the ischemic brain, which were examined by western blot analysis. (C) the relative NF-κB expression level; (D) the relative expression levels of the phosphorylated NF-κB; (E) (F) (B) The relative expression levels of its downstream Caspase 3/8/9, respectively, quantified and analyzed by using Gel-Pro analyzer software. Mean values ± SD (n = 3); Mean values ± SEM; * p < 0.05, ** p < 0.01 versus MCAO/R group; # p < 0.05, ## p < 0.01, versus sham group.