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. 2019 Sep 30;9(10):551. doi: 10.3390/biom9100551

Table 3.

Plant extracts with antidiabetic potential.

Species Extract Part of the Plant Dosage (mg/kg) Experimental Model Induction of Diabetes Reference
Acacia arabica chloroform bark 250, 500 male Wistar rats and albino mice alloxan [891]
chloroform bark 100, 200 female albino rats streptozotocin [892]
Achyranthes rubrofusca aqueous and ethanolic leaves 200 rats alloxan [893]
Albizzia lebbeck methanol/dichloro-methane stem bark 100, 200, 300, 400 male albino Wistar rats streptozotocin [894]
methanolic bark 200, 350, 620 female Sprague–Dawley rats streptozotocin-nicotinamide [895]
Aloe vera aqueous leaves 130 swiss albino mice streptozotocin [896]
ethanolic leaves 300 male albino Wistar rats streptozotocin [897]
Amaranthus tricolor methanolic whole plant 50, 100, 200, 400 male swiss albino mice glucose-induced hyperglycemia [898]
Anacardium occidentale aqueous leaves 175 male albino Wistar rats streptozotocin [899]
methanolic leaves 100 female albino mice streptozotocin [900]
Azadirachta indica ethanolic leaves 200 adult rabbits alloxan [901]
Barleria prionitis ethanolic leaves and root 200 adult albino rats alloxan [902]
Bauhinia thoningii aqueous leaves 500 Wistar albino rats alloxan [903]
Caesalpinia ferrea aqueous stem bark 300, 450 male Wistar rats streptozotocin [904]
Camellia sinensis crude tea leaves 0.5 mL/day male albino mice streptozotocin [905]
Casearia esculenta Roxb aqueous root 200, 300 male albino Wistar rats streptozotocin [906]
Cassia fistula ethanolic stem bark 250, 500 Wistar rats alloxan [907]
Cassia grandis aqueous and ethanolic stem 150 male albino Wistar rats alloxan [908]
Catharanthus roseus dichloromethane-methanol leaves and twigs 500 male Sprague–Dawley rats streptozotocin [909]
ethanolic leaves 100, 200 male Wistar rats streptozotocin [711]
Cecropia pachystachya methanolic leaves 80 male Wistar rats alloxan [910]
Ceriops decandra ethanolic leaves 30, 60, 120 male albino Wistar rats alloxan [911]
Chiliadenus iphionoides ethanolic aerial parts 1000 male and female diabetes-prone Psammomys obesus - [912]
Cinnamomum cassia ethanolic bark 200, 300 male Kunming mice streptozotocin [913]
Cinnamomum japonica ethanolic bark 200, 300 male Kunming mice streptozotocin [913]
Citrullus colocynthis aqueous root 2000 male and female Wistar rats and Swiss albino mice alloxan [914]
aqueous seed 1, 2 mL/kg male Wistar albino rats alloxan [915]
Coscinium fenestratum ethanolic stem 250 male albino Wistar rats streptozotocin-nicotinamide [916]
Eucalyptus citriodora aqueous leaves 250, 500 albino rats alloxan [917]
Gymnema sylvestre ethanolic leaves 100 male Sprague–Dawley rats streptozotocin [918]
Heinsia crinata ethanolic leaves 450–1350 rats alloxan [919]
Helicteres isora butanol and aqueous ethanol roots 250 male Wistar rats alloxan [920]
Momordica charantia aqueous pulp 13.33 g pulp/kg male albino Wistar rats alloxan [921]
ethanolic fruit 200 adult rabbits alloxan [901]
ethanolic fruit 400 male Sprague–Dawley rats streptozotocin [922]
Moringa oleifera methanolic pod 150, 300 Wistar albino rats streptozotocin [923]
- leaves 50 male Sprague–Dawley rats alloxan [924]
Murraya koenigii aqueous leaves 200, 300, 400 male albino rabbits alloxan [458]
ethanolic leaves 100, 250 male albino Swiss mice dexamethasone [925]
Opuntia ficus-indica petroleum ether stems 200 male ICR mice streptozotocin [926]
Origanum vulgare methanolic leaves 5 male C57BL/6 mice streptozotocin [927]
Passiflora nitida hydro-ethanolic leaves 50 female Wistar rats streptozotocin [928]
Paspalum scrobiculatum aqueous and ethanolic grains 250, 500 male Wistar albino rats alloxan [929]
Persea americana hydro-alcoholic leaves 150, 300 male Wistar rats streptozotocin [930]
aqueous seed 20, 30, 40 g/L male Wistar albino rats alloxan [931]
Phoenix dactylifera ethanolic leaves 50-400 male Wistar rats alloxan [932]
Phyllanthus niruri aqueous leaves 200, 400 male Wistar rats streptozotocin-nicotinamide [934]
Phyllanthus simplex petroleum ether, ethyl acetate, methanol and water fraction 100–400 rats alloxan [935]
Picralima nitida methanolic steam bark and leaves 75, 150, 300 Wistar rats streptozotocin [936]
Piper longum aqueous root 200, 300, 400 male Wistar albino rats streptozotocin [937]
Sonchus oleraceus hydro-alcoholic whole plant 75, 150, 300 Wistar rats streptozotocin [936]
Syzygium jambolana ethanolic seed 200 adult rabbits alloxan [901]
Tamarindus indica ethanolic stem bark 250, 500 Wistar rats alloxan [907]
ethanolic seed coat 500 Wistar albino rats alloxan [938]
Terminalia chebula chloroform seed 100, 200, 300 male Sprague–Dawley rats streptozotin [939]
Terminalia catappa petroleum ether, methanol and aqueous fruit 68, 40, 42 Wistar albino rats and mice alloxan [940]
Trigonella foenum-graecum ethanolic seed 100, 500, 1000, 2000 male Wistar albino rats alloxan [941]
hydro-alcoholic seed 500, 1000, 2000 Sprague–Dawley rats alloxan [942]
Vaccinium arctostaphylos ethanolic fruit 200, 400 male Wistar rats alloxan [943]
Vernonia amygdalina aqueous leaves 100 Wistar albino rats alloxan [944]
Witheringia solanacea aqueous leaves 500, 1000 male Sprague–Dawley rats GTT [945]
Zaleya decandra ethanolic roots 200 Wistar albino rats alloxan [946]
Zizyphus mauritiana petroleum ether, chloroform, acetone, ethanol and aqueous fruit 200, 400 female Wistar rats alloxan [947]

* unless otherwise noted, GTT glucose tolerance test; ICR Institute of Cancer Research.