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. 2019 Oct 19;9(10):629. doi: 10.3390/biom9100629

Table 1.

Human epidermal growth factor receptor 2 (HER2) extracellular domain mutations reported in previous studies from patient samples.

Protein Change Pfam Domain [8] Tumor Type Impact HER2 Phosphorylation Reference
L12R - Breast Cancer ND Negative ND * [35]
A20T Lung cancer ND ND ND [24]
L49H Lung cancer ND Negative ND [21]
L49H Glioblastoma ND ND ND [20]
E139D Receptor L Breast Cancer ND Negative ND [35]
E139G Breast Cancer ND Negative ND [35]
R157W Bladder cancer (MPUC) ND Negative ND [32]
T216S Furin-like Lung cancer ND Negative ND [21]
T216S Glioblastoma ND ND High [20]
I263T Colorectal cancer ND Negative ND [36]
G309A Breast Cancer Activating Negative ND [27]
G309E Breast Cancer Activating Positive ND [24]
S310F Gastric cancer Activating ND High [38]
S310F(2) Breast Cancer Negative High [26]
S310F Lung cancer Negative High [20]
S310F Breast Cancer Negative High [25]
S310F(2) Colorectal cancer Negative High [37]
S310F Breast Cancer Negative High [28]
S310F Lung cancer Positive High [22]
S310F Breast Cancer Negative High [29]
S310F(4) Bladder cancer (MPUC) Negative High [32]
S310F Adnexal cancer Negative High [33]
S310F Breast Cancer Negative High [29]
S310F(2) Breast Cancer Positive High [30]
S310F Lung cancer ND High [23]
S310F Breast Cancer Negative High [31]
S310F(4) Breast Cancer Positive ND [35]
S310Y Lung cancer Activating ND High [24]
S310Y Lung cancer ND High [20]
S310Y Colorectal cancer Positive High [21]
S310Y Bladder cancer (MPUC) Negative High [20]
C311R and E321G Lung cancer ND Negative ND [21]
C311R Glioblastoma ND ND Low [20]
N319D Lung cancer ND Negative ND [21]
N319D Glioblastoma ND ND ND [20]
E321G Glioblastoma ND ND Low [20]
D326G and C334S Lung cancer ND Negative ND [21]
D326G Glioblastoma ND ND Low [20]
C334S Glioblastoma ND ND ND [20]
A466T Receptor L Colorectal cancer ND Negative ND [36]
A466V Breast Cancer Activating Negative High [35]
C515R Growth factor receptor Breast Cancer Activating Negative High [35]
T526A Breast Cancer Activating Negative High [35]

* ND = no data available.