Table 2.
HER2 extracellular domain mutations reported in cell lines.
| Cell Line | Protein Change | Pfam Domain [8] | Lineage | Impact | Phosphorylation |
|---|---|---|---|---|---|
| SW1271 | S22N | - | Lung | ND * | ND |
| HEC59 | R100W | Receptor L | Endometrium | ND | ND |
| HEC108 | T166M | Endometrium | ND | ND | |
| SBC1 | Q178H | Lung | ND | ND | |
| MOLT16 | R217H | Furin-like | Haematopoietic and lymphoid tissue | ND | ND |
| NALM6 | R226H | Haematopoietic and lymphoid tissue | ND | ND | |
| KM12 | P230L | Large intestine | ND | ND | |
| DSH1 | D277H | Urinary | ND | ND | |
| 5637 | S310F | Urinary | Activating | High | |
| DSH1 | Urinary | ||||
| OACM51 | Oesophagus | ||||
| HRT18 | L313I | Intestine | ND | ND | |
| NCIH2110 | N319Y | Lung | ND | ND | |
| HCC1359 | T328S | Lung | ND | ND | |
| NCIH1563 | S335C | Lung | ND | ND | |
| Jurkat | S335I | - | Haematopoietic and lymphoid tissue | ND | ND |
| OC314 | A386T | Receptor L | Ovary | ND | ND |
| OC316 | A386T | Ovary | ND | ND | |
| NCIN87 | F425L | Stomach | ND | ND | |
| NCIN87 | L436V | Stomach | ND | ND | |
| SET2 | T444S | Haematopoietic and lymphoid tissue | ND | ND | |
| M059J | W452S | Central nervous system | ND | ND | |
| ISTSL1 | R499Q | - | Lung | ND | ND |
| SUPB8 | R499W | - | Haematopoietic and lymphoid tissue | ND | ND |
| Jurkat | T479M | Receptor L | Haematopoietic and lymphoid tissue | ND | ND |
| RL952 | G518V | Growth factor receptor | Endometrium | ND | ND |
| NCIH1793 | V541M | Lung | ND | ND | |
| NCIH740 | R558M | Lung | ND | ND | |
| Karpas45 | A586G | Haematopoietic and lymphoid tissue | ND | ND |
* ND = no data available.