. 2019 Sep 27;9(10):543. doi: 10.3390/biom9100543

Table 3.

Summary of allosteric activity of Hsp70s.

Bound Nucleotide/Substrate		Subdomain Conformation					Overall Subdomain Dynamics
NBD	SBD	Nucleotide binding cleft	Linker binding cleft	Linker	SBD	Lid	NBD	SBD
ATP	-	closed	open	docked	docked	released	rigid	flexible^(a)
ADP	-	open	closed	mobile	undocked	docked	flexible	rigid^(b)
-	peptide	open	closed	mobile	undocked	docked	flexible	rigid^(c)
ADP	peptide	open	closed	mobile	undocked	docked	flexible	flexible^(d)
ATP	peptide	closed	open	docked	docked	released	rigid	flexible^(e)
-	-	open	closed	mobile	undocked	released	flexible	flexible^(f)

Legends: NBD Nucleotide binding domain, SBD-Substrate binding domain, NB cleft-Nucleotide binding cleft, IA-IIA- NBD lobes IA and IIA. References in superscript a- [53]; b- [54], c- [52], d- [30], e- [49].