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. 2019 Oct 22;8(10):433. doi: 10.3390/plants8100433

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Genetic interactions between marginal and adaxial–abaxial patterning genes at the leaf margin. (A) WOX1/PRS inhibits the expression of the adaxial patterning gene AS2 and the abaxial patterning genes miR165/166. Inhibition of miR165/166 indirectly promotes expression of HD-ZIPIII genes in the adaxial domain but may also do so via other direct/indirect mechanisms. KAN, ETT/ARF3 and ARF4 can repress WOX1/PRS and WOX1/PRS can promote ARF4. Auxin biosynthesis at the margin is promoted by expression of the auxin biosynthesis gene YUC5, which is inhibited by KAN and promoted by HD-ZIPIII. (B-D) WOX1 and PRS activity in other plant species. (B) The petunia homolog of WOX1, MAW, promotes the expression of ETT/ARF3, ARF4, and KAN homologs. (C) In rice, the PRS orthologs NAL2 and NAL3 repress the expression of ETT/ARF3 and ARF4 homologs as well as the auxin biosynthesis genes YUC1 and YUC4. YUC8 is instead upregulated by NAL2/3. (D) The Medicago WOX1 protein STF can physically interact with the TPL and LUG corepressor proteins but also with the transcriptional activator AN3.