Table 1.
Mitochondrial phosphoprotein changes in hearts pretreated with NOC-18 versus ischemia.
| Mitochondrial Membrane-Bound Proteins | UniProt/SwissProt Number | Fold Change NOC-18/Ischemia | P-Value |
|---|---|---|---|
| Mitochondrial pyruvate carrier 1 (MPC1) | P63031 | 1.64 | 0.003 |
| NADH dehydrogenase ubiquinone flavoprotein 2 (NDUFV2) | P19234 | −1.53 | 0.009 |
| Very long chain specific acyl CoA dehydrogenase mitochondrial (ACADVL) | P45953 | 1.58 | 0.013 |
| Mitochondrial 2 oxoglutarate malatecarrier protein (SLC25A11) | P97700 | 1.66 | 0.013 |
| ADP/ATP translocase 1 (SLC25A4) | Q05962 | 1.57 | 0.022 |
| ATP synthase subunit alpha mitochondrial (ATP5A1) | P15999 | 1.55 | 0.028 |
| Trifunctional enzyme subunit beta mitochondrial (HADHB) | Q60587 | 1.61 | 0.032 |
| Electron transfer flavoprotein ubiquinone oxidoreductase mitochondrial (ETFD) | Q6UPE1 | 1.63 | 0.041 |
| Cytochrome c oxidase subunit 4isoform 1 mitochondrial (COX4I1) | P10888 | 1.54 | 0.042 |
| Cytochrome b c1 complex subunit Rieske (UQCRFS1) | P20788 | 1.54 | 0.043 |
| Mitochondrial Matrix Proteins | |||
| Pyruvate dehydrogenase E1 component subunit alpha somatic form mitochondrial (PDHA1) | P26284 | 1.55 | 0.024 |
| Short chain specific acyl CoAdehydrogenase mitochondrial (ACADS) | P15651 | 1.58 | 0.027 |
| Long chain specific acyl CoAdehydrogenase mitochondrial (ACADVL) | P15650 | 1.59 | 0.027 |
| Isovaleryl CoA dehydrogenase mitochondrial (IVD) | P12007 | 1.59 | 0.030 |
| Succinyl CoA ligase ADP GDP forming subunit alpha mitochondrial (SUCLG1) | P13086 | 1.62 | 0.030 |
| Lon protease homolog mitochondrial (LONP1) | Q924S5 | 1.75 | 0.032 |
| Hexaprenyldihydroxybenzoatemethyltransferase mitochondrial (COQ3) | Q63159 | 1.67 | 0.032 |
| Citrate synthase mitochondrial (CS) | Q8VHF5 | 1.57 | 0.034 |
| 3-ketoacyl CoA thiolase mitochondrial (ACAA2) | P13437 | 1.57 | 0.044 |
| Malate dehydrogenase mitochondrial (MDH2) | P04636 | 1.54 | 0.049 |
The identified proteins were categorized based on subcellular location. Fold change expressed as NOC-18 versus Ischemia (p ≤ 0.05 of t-test statistics presented in ascending order). (−) indicates decreased phosphorylation level after NOC-18 treatment.