Figure 1.

Representative images of extracellular matrix components in nasal polyps. Nasal polyps from subjects with different phenotypes of chronic rhinosinusitis were examined for extracellular matrix content by direct staining or through immunofluorescence. For immunofluorescence, a primary antibody directed against the various matrix components and an APC-labeled secondary antibody (red) with DAPI (4′, 6-diamidino-2-phenylindole) nuclear stain (blue) was used. Representative examples of each matrix component tested are shown. A, Sirius red. B, Isotype control. C, Collagen I. D, Collagen III. E, Collagen IV. F, Fibronectin (For interpretation of the references to colours in this figure legend, refer to the online version of this article).