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. 2019 Oct 22;9(10):638. doi: 10.3390/biom9100638

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of PER on the activity of M-type K⁺ (KM) channels recorded from mHippoE-14 cells. In these cell-attached single-channel recordings, the cells were bathed in high-K⁺, Ca²⁺-free solution, the recording pipette was filled with low-K⁺ (5.4 mM) solution and the potential was held at +30 mV relative to the bath. (A) Superimposed KM-channel traces in the absence (upper) and presence (lower) of 1 μM PER. Of note, the opening events caused the upper deflections of the trace in this on-cell patch. (B) Summary bar graph showing the effects of PER and PER plus flupirtine on the probabilities of KM channels that would be open (mean ± SEM; n = 11 for each bar). (1): controls; (2): 1 μM PER; (3): 3 μM PER; (4) 3 μM PER plus 10 μM flupirtine. * Significantly different from the controls (p < 0.05) and Ϯsignificantly different from the PER (3 μM) alone group (p < 0.05).

Effect of PER on the activity of M-type K⁺ (KM) channels recorded from mHippoE-14 cells. In these cell-attached single-channel recordings, the cells were bathed in high-K⁺, Ca²⁺-free solution, the recording pipette was filled with low-K⁺ (5.4 mM) solution and the potential was held at +30 mV relative to the bath. (A) Superimposed KM-channel traces in the absence (upper) and presence (lower) of 1 μM PER. Of note, the opening events caused the upper deflections of the trace in this on-cell patch. (B) Summary bar graph showing the effects of PER and PER plus flupirtine on the probabilities of KM channels that would be open (mean ± SEM; n = 11 for each bar). (1): controls; (2): 1 μM PER; (3): 3 μM PER; (4) 3 μM PER plus 10 μM flupirtine. * Significantly different from the controls (p < 0.05) and Ϯsignificantly different from the PER (3 μM) alone group (p < 0.05).