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. 2019 Sep 20;55(10):616. doi: 10.3390/medicina55100616

Figure 3.

Figure 3

Effect of pedunculopontine nucleus (PPN) neurotoxic lesion on the nicotinic cholinergic receptors (α7 nAChRs) mRNA expression in nigral tissue. (A) Comparison between experimental groups 24 h (F (2, 14) = 10.31 p < 0.001), 48 h (F (2, 17) = 8.52 p < 0.001) and seven days (F (2, 15) = 7.12 p < 0.01) after the lesion. The first bar (white bar) represents the non-operated group. This group is common for the ANOVA statistical analysis, which was carried out among non-operated, PPN lesion and sham-operated groups for each time post lesion separately. The asterisks correspond to statistical differences between PPN lesion and both control groups (non-operated and sham operated). (B) Agarose/ethidium bromide gel electrophoresis bands representatives of the semi-quantitative RT-PCR study for α7 nAChRs mRNA expression. *** p < 0.001; ** p < 0.01.