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. 2019 Oct 6;10(23):5820–5831. doi: 10.7150/jca.30865

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Antitumor effects of UA-PMs on H22 xenograft model. The H22 tumor-bearing mice in each group were treated every other day for 6 times from the 5th day on after inoculation with the different formulations as: (a) Saline, (b) Empty PMs, (c) UA (50 mg/kg), (d) 5-FU (25 mg/kg), (e) UA-PMs (25 mg/kg), (f) UA-PMs (50 mg/kg), (g) UA-PMs (100 mg/kg). Results described the mean tumor size of mice (A), tumor weight (B), survival curve of tumor-bearing mice (C), mean for survival time (D) and weight of mice (E). Data are shown as the mean ± SD in each group (n=5). Significant differences were observed between treated groups and saline (*P< 0.05, **P< 0.01), treated groups and 5-FU group (^#P< 0.05, ^##P< 0.01), UA and UA-PMs (^★P < 0.05) at the concentration of 50 mg/kg.