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. 2019 Oct 6;10(23):5812–5819. doi: 10.7150/jca.30720

Figure 5.

Figure 5

ERRα promotes CRC cell migration via OTUB1. HCT116 (A) or Caco2 (C) cells were transfected with ERRα expression plasmid (or empty vector) with or without OTUB1 siRNAs for 24 h. Then, 0.5 × 105 HCT116 cells or 1.5 × 105 Caco2 were seeded into a Boyden chamber for 24 to 36 h to assay cell migration. HCT116 (B) or Caco2 (D) cells were transfected with an ERRα siRNA (or siNC) with or without OTUB1 expression plasmid for 24 h. Then, 0.5 × 105 HCT116 cells or 1.5 × 105 Caco2 were seeded into a Boyden chamber for 24 to 36 h to assay cell migration. Representative images are shown. The relative magration of cells is indicated on the right. Bars represent the mean ± SD of three independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001.