Table 3 –
Clinical factor of interest in model | A1CDCCT/EDIC < 7.5% | DCCT/EDIC ≥ 7.5% | ||||
---|---|---|---|---|---|---|
Model 1a | Model 2b | Model 1a | ||||
RR(95%CI) | p | RR(95%CI) | p | RR(95%CI) | p | |
DCCT-severe hypoglycemia rate | 1.34(1.07–1.68) | 0.009 | 1.30(1.04–1.64)c | 0.02 | 1.03(0.86–1.23) | 0.76 |
DCCT-ACI | 0.93(0.51–1.68) | 0.79 | 1.08(0.58–2.01) | 0.82 | 1.18(1.03–1.36) | 0.02 |
Model 1: baseline age, gender, DCCT-A1C, DCCT-severe hypoglycemia rate.
Model 2: baseline age, gender, DCCT-A1C, DCCT-severe hypoglycemia rate, baseline diabetes duration, baseline neuropathy, baseline-AER, smoking status, LDL-cholesterol, systolic blood pressure, BMI and DCCT-A1C. Since p-values for baseline hypoglycemia, group treatment and baseline retinopathy were large, these factors were not included in model.
Scanning site or Eligibility-HbA1C instead of DCCT-A1C did not significantly modify the relationship between severe hypoglycemia and CAC.