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. Author manuscript; available in PMC: 2020 Aug 6.
Published in final edited form as: Biochemistry. 2019 Jul 24;58(31):3354–3364. doi: 10.1021/acs.biochem.9b00327

Figure 2.

Figure 2.

(a) Sequence similarity network of COG0524 at an alignment score of 35. (b) Sequence similarity network of COG0524 at an alignment score of 60. At this alignment score all of the known catalytic functions have been separated into single clusters and thus the SSN is probably isofunctional. Abbreviation for enzymes are as follows: rbks-ribokinase (Uniprot: P0A9J6); kdgk-2-dehydro-3-deoxygluconokinase (Uniprot: P37647); frk1/frk2-fructokinase1/2 (Uniprot: Q6XZ78/Q0JGZ6); psuK-pseudouridine kinase (Uniprot: P30235); adoK-adenosine kinase (Uniprot: P9WID5); TK2029-ADP-dependent ribose-1-phosphate kinase from Thermococcus kodakarensis (Uniprot: Q5JDG9); mik-inositol 3-kinase (Uniprot: Q5GA22); MJ0406-nucleoside kinase from Methanocaldococcus jannaschii (Uniprot: Q57849); gsk-inosine-guanosine kinase (Uniprot: P0AEW6); pfkb-ATP-dependent 6-phosphofructokinase (Uniprot: D9TT10); and frld-fructoselysine 6-kinase (Uniprot: P45543).