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. Author manuscript; available in PMC: 2019 Nov 11.
Published in final edited form as: Adv Drug Deliv Rev. 2018 Jul 21;130:113–130. doi: 10.1016/j.addr.2018.07.009

Figure 2.

Figure 2.

(A) Half-life extension mechanisms of acylated GLP-1 analogs. (B) Mean concentration-time profile of liraglutide following single dose of 0.6 mg, 1.2 mg, or 1.8 mg at steady state in healthy male Chinese subjects. Adapted with permission of © John Wiley & Sons, Inc. from Jiang et al. J Clin Pharmacol. 2011;51:1620–7. [72] (C) Mean concentration-time profile of semaglutide following single dose of 1.0 mg at steady-state. Adapted with permission of © John Wiley & Sons, Inc. from Kapitza et al. J Clin Pharmacol. 2015; 55(5):497-504. [73]