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. 2019 Nov 11;17:115. doi: 10.1186/s12951-019-0546-3

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a Conjugation reaction of ClTx to DSPE-PEG-NHS. b Graphical representation of CADOX-LIP-LIP. c Cryo-TEM images of non-functionalized LIP and CADOX-LIP-LIP. Image inset is a magnification of a single liposome carrying DOX. d Characterization of LIP by Dynamic Light scattering and ζ-potential analyser. Data are expressed as a mean ± SD of at least three independent LIP preparation, each of them in triplicates