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. 2019 Nov 11;19:1082. doi: 10.1186/s12885-019-6299-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Restricted spline curves for the associations between percentage change in BMI and cancer-related mortality among overall (a), under/normal weight (b), overweight (c) and obese (d) participants. The solid curve represents the multivariate-adjusted HRs calculated by restricted cubic splines with 3 knots at the 25th, 50th, and 75th of the percentage change in BMI; the solid dashed lines represent corresponding 95% confidence interval. The reference value (HR = 1) was set at BMI percentage change = 0. HRs were estimated by cox proportional hazard model adjusted of sex, age, race, education level, family annual income, marital status, physical activity level, family history of cancer in their first-degree relatives, smoking status, screening arm, history of chronic diseases (i.e., hypertension, heart attack, stroke, emphysema, diabetes, arthritis, and osteoporosis), and BMI value at study entry (continuous)