Table 4.

Major key methodological findings

Most frequent risk of biases	Random sequence generation, allocation concealment, baseline characteristics, baseline outcome measurements similar, and contamination between intervention and comparator
Study designs	Not restricted to RCTs or cluster RCTs
Economic quality criteria	Most criteria are met but there are some issues: not detailing target population; not describing “usual care” comparators; not including patient costs, indirect costs or intervention fees; analytical methods poorly described; incremental costs and outcomes sometimes not reported; not accounting for uncertainty
Heterogeneity	In populations, interventions and some outcomes
Equity	Not assessed
Process dimensions	Process dimensions that impact dissemination and external validity poorly described.

RCT randomized controlled trial