Table 2.

Peptides decreasing >2-fold in both experimental (CDK12^as = ‘as’) and control (CDK12^WT = ‘WT’) experiments. Phosphorylated residue indicated in the ‘Peptide’ column.

Protein	Peptide	Fold Change		Potential Protein Kinase
		‘as’	‘WT’
HDAC4	SSPLLR (S266)	−2.7	−5.8	PIM1; PRKG1; PIM3
AHNK	VSMPDVELNLKSPK (S3426)	−3	−2.7	JNK1/3; P38d (MAPK13)
ANLN	TQSLPVTEK (S485)	−4.3	−2.5	ANPa; COT; ANPb;
RAB34	INSDDSNLYLTASK (S241)	−2.5	−2.4	MAPKAPK3; ANPa; PRKG2
NF1	SFDHLISDTK (S2543)	−4.1	−2.2	PIM1/3; MSK1
WDCP	DSFSHSPGAVSSLK (S690)	−2.6	−2	ERK1/2/5
AFAP1	LSSERPSSDGEGVVE… (S283)	(+)2.1	(+) 3.4	CK2a2 (CSNK2A2); CK2a1 (CSNK2A1); MAPKAPK3