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Possible involvement of mdig in regulating the stemness of stem cells. A. Expression levels of mdig in oocyte, zygote, 2-cell blastomere, early blastomere, and ESCs. Data are derived from scRNASeqDB (https://bioinfo.uth.edu); B. RNA-seq data indicated that knockout of mdig through CRISPR-Cas9 approach resulted in down-regulation of the stemness genes featured in hematopoietic stem cells and neural stem cells as analyzed by StemChecker (stemchecker.sysbiolab.eu).
