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. 2019 Oct 24;4(19):18478–18486. doi: 10.1021/acsomega.9b03208

Figure 6.

Figure 6

Effects of PI3K pathway inhibitor LY294002 and activator 740Y-P on the morphology and activity of DON-injured cells. IPEC-J2 cells were cultured with or without DON (1 μM) and PI3K pathway activator 740Y-P (20 μM)/inhibitor LY294002 (10 μM) for 12 h. (A) Morphology of IPEC-J2 cells in control group. (B) Morphology of IPEC-J2 cells in DON group. (C) Morphology of IPEC-J2 cells in LY294002 group. (D) Morphology of IPEC-J2 cells in 740Y-P group. (E) Effects of 740Y-P and LY294002 on DON-induced activity of IPEC-J2 cells. ## means P ≤ 0.01 vs the healthy control group; ** means P ≤ 0.01 vs DON group; * means P ≤ 0.05 vs DON group.