TABLE 3.

Univariable and multivariable Cox regression analyses for survival benefit (PFS and OS)

	Univariable		Multivariable
	HR (95% CI)	Signif	HR(95% CI)	Signif
PFS
Age at treatment	0.99 (0.95, 1.02)	0.44	0.98 (0.95, 1.02)	0.35
Number of cycles	0.97 (0.90, 1.04)	0.43	0.97 (0.90, 1.04)	0.34
Received CTX in the past
No	Ref.
Yes	0.84 (0.43, 1.67)	0.63	0.75 (0.37, 1.52)	0.43
Number of prior lines of palliative chemo
None	Ref.
≥1	0.98 (0.54, 1.78)	0.96	0.98 (0.54, 1.77)	0.93
OS
Age at treatment	0.99 (0.96, 1.02)	0.48	0.98 (0.95, 1.02)	0.34
Number of cycles	0.85 (0.78, 0.92)	<0.001	0.84 (0.77, 0.91)	<0.001
Received CTX in the past
No	Ref.
Yes	0.90 (0.48, 1.71)	0.75	0.60 (0.30, 1.20)	0.15
Number of prior lines of palliative chemo
None	Ref.
≥1	1.03 (0.58, 1.83)	0.91	0.91 (0.51, 1.64)	0.76

CI, confidence interval; HR, hazard ratio; OS, overall survival; PFS, progression-free survival; Ref.,reference; Signif, significance.