Table 4.
Clinical and biochemical profile of patients of fibrocalculous pancreatic diabetes with cardiac autonomic neuropathy (CAN) as compared to those without CAN
| Parameter | FCPD with CAN (n=36) | FCPD without CAN (n=54) | P |
|---|---|---|---|
| Age (years) | 35.51±9.61 | 33.8±10.9 | 0.581 |
| Male:Female | 16:20 | 23:31 | 0.862 |
| Duration of diabetes (years) | 6 [3–9] | 3 [1–11.75] | 0.127 |
| BMI (kg/m2) | 18.93±3.65 | 17.92±2.72 | 0.138 |
| Waist Circumference (cm) | 71.61±9.24 | 72.33±8.19 | 0.753 |
| Fasting C-peptide (ng/ml) | 0.76±0.36 | 0.86±0.58 | 0.435 |
| 1hour post meal C-peptide (ng/ml) | 1.44±0.88 | 1.57±0.98 | 0.583 |
| Fecal Elastase (µg elastase/g stool)a | 7.5 [3.5–13.75] | 10 [5–20] | 0.048 |
| HbA1c (%) | 10.12±2.33 | 9.28±2.12 | 0.081 |
| Ketosis | 2 | 1 | 0.351 |
| Steatorrhea | 33 | 35 | 0.003 |
| Peripheral Neuropathy | 21 | 3 | 0.002 |
| Retinopathy | 5 | 0 | 0.157 |
| Nephropathy | 27 | 14 | <0.001 |
| Percent Body Fat (%) | 16.77±9.87 | 15.84±8.93 | 0.643 |
| Total Cholesterol (mg/dl) | 165.3±42.43 | 147±31.4 | 0.024 |
| LDL-C (mg/dl) | 93.11±33.2 | 88.6±19.5 | 0.430 |
| HDL-C (mg/dl) | 50.3±17.8 | 43.5±9.2 | 0.022 |
| Triglycerides (mg/dl) | 135.6±17.9 | 133.6±63.66 | 0.884 |
| Creatinine (mg/dl) | 0.93±0.17 | 0.90±0.17 | 0.437 |
| Spot urine ACR (mg/gm)a | 58.9 [17.7-73] | 19 [8.98-32.0] | 0.001 |
ACR: Albumin creatinine ratio; BMI: Body mass index; CAN: Cardiac autonomic neuropathy; DM: Diabetes; LDL: Low density lipoprotein; FCPD: Fibrocalculous pancreatic diabetes; HDL: High density lipoprotein; HbA1c: Glycated hemoglobin; GFR: Glomerular filtration rate; All continuous variables expressed as mean (standard deviation); aall non-normally distributed variable expressed as median [inter quartile range]; all discreet variables have been expressed as absolute numbers (percentage); normality checked using Kolmogorov-Smirnov test; P<0.05 considered statistically significant; #P–value calculated using Chi-square test; Retinopathy was diagnosed using EDTRS criteria; presence of nephropathy was defined as glomerular filtration rate (CKD-EPI) <60 ml/min and/or presence of microalbuminuria/overt proteinuria; presence of peripheral neuropathy was defined as defect in 10 gm Semmes-Weinstein monofilament test and/or impaired vibration perception threshold test with/without symptoms of neuropathy. Numbers in bold indicate values of statistical significance