Table 1.
Samples included in the GWAS.
| Lymphopenia status | SPL | MPL | No lymphopenia | Total |
|---|---|---|---|---|
| Definition | ALC <0.5 × 109/L for ≥6 months | ALC <0.8 × 109/L for ≥6 monthsa | ALC always >0.91 × 109/L (LLN) | |
| Number analyzed | 42 | 164 | 1,052 | 1,258 |
| Age, mean (SD) | 43.7 (8.3) | 40.9 (7.8) | 37.8 (9.1) | 38.4 (9.0) |
| Female, n (%) | 35 (83) | 121 (74) | 738 (70) | 894 (71) |
| Years since diagnosis, mean (SD) | 5.2 (5.23) | 5.5 (5.74) | 5.1 (5.21) | 5.2 (5.28) |
| Relapses in prior year, mean (SD) | 1.4 (0.70) | 1.3 (0.56) | 1.3 (0.64) | 1.3 (0.64) |
| EDSS, mean (SD) | 2.75 (1.32) | 2.45 (1.15) | 2.42 (1.22) | 2.44 (1.22) |
| Mean baseline ALC (SD) | 1.64 (0.43) | 1.68 (0.71) | 2.07 (0.60) |
ALC, absolute lymphocyte count; EDSS, Expanded Disability Status Scale; GWAS, genome-wide association study; LLN, lower limit of normal; MPL, moderate prolonged lymphopenia; SPL, severe prolonged lymphopenia. All samples were of European ancestry.
a
Excludes patients in the SPL category (ALC <0.5 × 109/L for ≥6 months).