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Samples included in the gene expression analysis.
| Lymphopenia status | DMF twice daily | DMF 3 times daily | Placebo to extension | Total |
|---|---|---|---|---|
| SPL | 15 | 9 | 18 | 42 |
| MPL | 54 | 40 | 55 | 149 |
| No lymphopenia or mildly reduced lymphocytesa | 284 | 315 | 343 | 942 |
DMF, delayed-release dimethyl fumarate; MPL, moderate prolonged lymphopenia; SPL, severe prolonged lymphopenia.
Absolute lymphocyte count (ALC) <0.91 × 109/L (lower limit of normal) at any point, but ALC not <800 cells/μL for ≥6 months.
